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渡邉 茂樹; 石岡 典子; Liang, J. X.; 花岡 宏史*; 飯田 靖彦*; 遠藤 啓吾*
no journal, ,
Br (t = 16.2 h, = 57%, EC = 43%) has intermediated half-life and may have great potentials as radionuclide for positron emission tomography (PET). We have produced Br via the Se(p,n)Br reaction using CuSe target by AVF cyclotron in JAEA, and also have interest in bromine labeled radiopharmaceuticals. Radioiodine labeled m-iodobenzylguanidine (MIBG) such as [I]-MIBG have been widely employed for heart function and tumor imaging with SPECT. In contrast, PET is superior in quantitative measurement and Br labeled bromobenzylguanidine (MBBG) can be expected to employ as a novel imaging reagent with PET. In this work, we synthesized radioactive Br labeled MBBG using Br and evaluated the chemical properties and stability of Br-MBBG.